An interactive encyclopedia of Psilocybe cubensis strains, potency data from lab-verified competition results where available, experience profiles, and evidence-based harm reduction guidance.
Filter, sort, and explore detailed profiles for every documented Psilocybe cubensis variety. Potency data sourced from lab-verified competition results (Oakland Hyphae Cup, Cultivar Cup) where available; community estimates otherwise. Click any card to expand full details.
Total tryptamine percentages (psilocybin + psilocin + minor alkaloids) by dry weight. Data from lab-verified competition results (Oakland Hyphae Cup, Cultivar Cup) where available; community estimates otherwise. Competition samples are cherry-picked; typical results will be lower.
Visualize roughly how dose and strain potency shape the psilocybin experience over time. An illustration loosely calibrated to clinical data for pure psilocybin (Holze et al., 2023); individual timing varies widely.
Marks where you are on this timeline, using the dose, strain and method selected above. Saved only on this device. It can chime at each stage while this page is open; for alerts on a locked phone, add them to your calendar once it's running.
Chimes play only while this page is open with the screen on, and an iPhone in silent mode mutes them. Calendar alerts and reminders work on a locked phone: each adds one entry per remaining stage, titled like "Session: Peak".
"Send to Reminders" hands the remaining stages to a shortcut on your iPhone, iPad or Mac, which adds one reminder per stage with an alert at its time. Build the shortcut once in the Shortcuts app:
The first time it runs, iOS asks you to allow it. Reminders don't change if you later adjust the start time or end the session.
Compare subjective effect profiles across 8 dimensions. Select one or two strains to overlay. Based on community reports and clinical observation data.
Select any two strains for a detailed statistical comparison with visual difference indicators.
Evidence-based dose recommendations adjusted by strain potency and experience level. Research shows body weight does not significantly affect psilocybin response (Garcia-Romeu et al., 2021).
All strains rated across five cultivation dimensions. Filled dots indicate better performance. Sorted by overall ease of cultivation.
| Strain | Contam. Resistance | Colonization Speed | Fruiting Reliability | Substrate Versatility | Clone Stability | Overall |
|---|
Evidence-based guidance informed by clinical research from Johns Hopkins, Imperial College London, and MAPS/Zendo Project protocols.
Call 911 (or your local emergency number) right away for a seizure, loss of consciousness, trouble breathing, chest pain, or if anyone is at risk of harming themselves or others. Tell responders what was taken — they are there to help.
Based on systematic reviews and clinical trial data. Always consult a physician before combining any substances.
Risk: Seizures and delirium. Analysis of experience reports found 47% of lithium + psychedelic combinations involved seizures. 39% required medical attention. This is an absolute contraindication. Note: Lamotrigine does NOT carry this risk (0% seizure rate).
Risk: Serotonin toxicity, hypertensive crisis. MAO-A inhibition blocks psilocin metabolism, potentially causing dangerous serotonin accumulation. Minimum 2-week washout for irreversible MAOIs, 2-3 days for moclobemide.
Risk: Seizures and serotonin syndrome. Tramadol has serotonin reuptake inhibition plus independent seizure risk. Combined with psilocybin's serotonergic activity, risk compounds. Avoid this combination.
Effect: ~50% of users report significantly weakened psilocybin effects due to 5-HT2A receptor downregulation. Serotonin syndrome has NOT been documented in clinical studies. Low acute danger but substantially reduced benefit. Never abruptly discontinue SSRIs.
Similar to SSRIs: likely blunted effects. Higher noradrenergic activity at higher doses adds theoretical complexity. Consult prescribing physician.
Can intensify and alter the experience unpredictably, potentially increasing anxiety. No controlled studies. Avoid during psilocybin experiences, especially for less experienced users.
Used as first-line rescue medication in clinical trials (10-30mg oral diazepam). Reduces anxiety without fully blocking the experience. Low interaction risk; appropriate as safety medication.
Block or attenuate effects via 5-HT2A antagonism. Can serve as "trip killers" but not recommended routinely due to side effect profiles.
Timing food intake relative to dosing significantly affects onset, intensity, and nausea.
Light meal 2-4 hours before dosing, then fast until ingestion. Best balance of reliable absorption, stable blood sugar, and reduced nausea risk.
Fastest onset (20-30 min). Strongest intensity. But paradoxically higher nausea risk.
Moderate onset (30-45 min). Strong intensity. Lower nausea. The recommended balance.
Slowest onset (45-90 min). Reduced intensity. Fatty foods worst.
A pre-digestion technique using citric acid. The theory is that lemon juice (pH ~2.0) facilitates dephosphorylation of psilocybin to psilocin outside the body. Mechanism plausible but unconfirmed in controlled studies.
Use a coffee grinder to reduce dried mushrooms to the finest powder possible. Maximizes surface area.
Place powder in a glass. Squeeze 1-2 fresh lemons (enough to fully cover). Fresh juice preferred over bottled.
Stir every 5 minutes. The mixture will darken. This is the conversion window.
Filter through cheesecloth to remove mushroom material. May further reduce nausea.
Consume entire liquid. Can mix with water, ginger tea, or honey to improve taste.
Ginger (Zingiber officinale) is well-established as an antiemetic. Active compounds (gingerols, shogaols) act as 5-HT3 receptor antagonists -- the same mechanism as ondansetron (Zofran).
Allows ginger compounds to absorb and begin antiemetic action before mushroom ingestion.
Fresh ginger root tea: Slice/grate 1-2 inches, steep 10-15 min (best).
Ginger capsules: 500-1000mg standardized extract.
Crystallized ginger: Eat several pieces.
Ginger tea bags: Less potent but accessible.
Keep ginger tea or candied ginger on hand. Can consume more if nausea arises during the experience.
Use fresh ginger tea as the liquid for lemon tek. Addresses nausea from two angles: ginger's antiemetic action plus lemon tek's faster absorption and chitin breakdown.
Based on clinical protocols from Johns Hopkins (Johnson et al., 2008) and Imperial College London.
Based on the Zendo Project's Four Principles of Psychedelic Peer Support (MAPS). Remember: difficult is not the same as bad. If it is a medical emergency, or you want to talk to a person, use the Get help now numbers above.
Click the circle to start a guided breathing rhythm: 4 seconds in, 4 seconds hold, 4 seconds out.
Mycological, pharmacological, and cultivation terminology used throughout this guide.